abstract |
There are ring-narrowed N-desmethyl-N-isopropyl-erythromycin-A-spiroacetal derivativesnof formula I with gastrointestinally effectivenmotilin-agonistic properties and their production described.n n n [(1'R), 2R, 3S, 4S, 5R, 6R, 9R, 11R, 12R, 14R] -11- (1'-hydroxypropyl) -2,4,6,8,11,14-hexamethyl-10 , 13,15-trioxatricyclo- [9.2.1.1 9.6 ] -pentadecan-1-one derivatives of the general formula I wherein R 1 is methyl or hydrogen, and their stable and physiologically acceptable acid addition salts. |