http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0837056-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7ee05e5af286e73261ac75cee30782d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B40-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-40 |
| filingDate | 1997-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b35aba8fc059bf4735f5a124b4b5072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_848f17f1f6625b06577b0b12f05408db |
| publicationDate | 2000-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0837056-A3 |
| titleOfInvention | Combinatorial reagent synthesis and intermediates therefor |
| abstract | a) eine Harz-Linker-Verbindung der Formel [Harzpolymer]-[L-Nuc] n (II)nworin nucleofuge Gruppen Nuc über den Linker L an ein Harz [=Harzpolymer]ngebunden sind, mit einem Acylsulfonamid der Formel E 1 -SO 2 -NH-CO-E 2 (III)nworin E 1 und E 2 unabhängig voneinander jeweils einen für die Herstellung dernReste R 1 bzw. R 2 in Verbindung (I) geeigneten organischen Rest bedeuten,nin Gegenwart eines Kondensationsmittels zu einem harzgebundenen Addukt dernFormel (IV),n nworin [Harzpolymer], L, n, E 1 und E 2 wie in Formel (II) bzw. Formel (III) definiertnsind, umsetzt, b) das erhaltene Addukt (IV) in einem oder mehreren weiterennReaktionsschritten an den organischen Resten E 1 bzw. E 2 zu den Resten R 1 bzw.nR 2 derivatisiert wird, und c) aus dem erhaltenen Harz-Linker-Addukt der Formel (IV ) die Verbindung dernFormel (I) abspaltet. The invention relates to a resin-bound synthesis process for the preparation of chemical compounds of the formula (I), R 1 -SO 2 -NH-CO-R 2 wherein R 1 and R 2 each represent an organic radical, characterized in that a) a resin-linker compound of the formula [resin polymer] - [L-Nuc] n (II) in which nucleofugic groups Nuc are linked via the linker L to a resin [= resin polymer], with an acylsulfonamide of the formula E 1 -SO 2 -NH-CO-E 2 (III) wherein E 1 and E 2 each independently represent an organic radical suitable for the preparation of the radicals R 1 or R 2 in compound (I), in the presence of a condensing agent to give a resin-bound adduct of the formula (IV), in which [resin polymer], L, n, E 1 and E 2 are as defined in formula (II) or formula (III), b) the adduct (IV) obtained is derivatized in one or more further reaction steps on the organic radicals E 1 or E 2 to the radicals R 1 or R 2 , and c) from the resin-linker adduct of the formula (IV ) cleaves the compound of formula (I). |
| priorityDate | 1996-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.