| abstract |
Complexes of p53 with the transcription factors DP-1 (and other members of the DP family) or E2F-1 (or other E2F proteins, up to and including E2F-5), are disclosed. These novel complexes can be used to assay for potential chemotherapeutic agents that are p53 agonists or antagonists, particularly agonists or antagonists which modulate progression through the cell cycle by disruption of the normal binding of p53 to DP-1 and/or E2F-1. |