| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68cdc4b020ae1cec80f5bc89c4d22793 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3046
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-31 |
| filingDate |
1997-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2005-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed448656c103cab0c5ca32612b50358c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e88a6ca7347deeb7e584f15ab7dd69d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccf5e6fcd220be16e304cfabf03279be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a7d5af491f0b5722388e0a2b5a7983f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13848be826ec49d203dd3f8a5a51a37a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc586fccab74b1867a27468c920e06d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f18c23c6856fc431e1b199aa5266ad2f |
| publicationDate |
2005-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0835266-B1 |
| titleOfInvention |
Modified/chimeric superantigens and their use |
| abstract |
A novel conjugate comprises a target seeking moiety and a modified wild type superantigen; the modified superantigen retains its ability to activate a subset of T cells, even though 1 or more wild-type amino acid residues in at least 1 region which functions in determining binding to T cell receptor (TCR)and activation of a subset of T cells has/have been replaced. Also claimed is the use of a modified superantigen as above, optionally as part of a conjugate with a target seeking moiety, for activating the immune system to treat a mammalian disease. Also new is a pharmaceutical composition comprising a modified antibody (preferably a Fab fragment fused to a peptide moiety providing activation of T cells in V~b specific manner) in which cysteines providing for interchain cysteine linkages in the native antibody have been replaced (preferably by serine residues) to prohibit cystine formation. |
| priorityDate |
1996-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |