| abstract |
Novel fused polycyclic heterocycle derivatives havingnexcellent antitumor effects and a process for producing thensame. n A compound represented by the following general formulan(I) or pharmacologically acceptable salts thereof:n nwherein the ring A represents an optionally substitutednmonocyclic aromatic ring or a dicyclic fused ring in which atnleast one of the rings is an aromatic ring; the ring B representsnpyrrole, 4H-1,4-oxazine, 4H-1,4-thiazine or 4(1H)-pyridone;nthe ring C represents an optionally substituted, monocyclic orndicyclic fused aromatic ring; and Y represents a groupnrepresented by the formula -e-f (wherein e represents a lowernalkylene; and f represents amidino, guanidino or aminonoptionally substituted by optionally hydroxylated ornoptionally lower-alkylaminated lower alkyl; n provided that the cases where the rings A and B are both noptionally substituted monocyclic aromatic rings are excluded. n Which has an excellent antitumor activity. |