| abstract |
The instant invention provides dihydronaphthalene andnnaphthalene compounds, intermediates, formulations, andnmethods for use in the treatment of bone loss or bonenresorption . The dihydronaphthalene compounds have the formula:n nwhereinn R 1 is -H, -OH, -O(C 1 -C 4 alkyl), -OCO(C 1 -C 6 alkyl),n-O-CO-O(C 1 -C 6 alkyl) , -O-CO-Ar, -OSO 2 (C 2 -C 6 alkyl), -O-CO-OAr,nwhere Ar is optionally substituted phenyl; R 2 is -H, -Cl, -F, C 1 -C 4 alkyl, -OH, -O(C 1 -C 4 nalkyl), -OCO(C 1 -C 6 alkyl), -O-CO-O(C 1 -C 6 alkyl), -O-CO-Ar,-OSO 2 (C 2 -C 6 nalkyl), or -O-CO-OAr, where Ar is optionallynsubstituted phenyl; R 3 and R 4 are, independently, R 2 , with the provisonthat both R 3 and R 4 are not both. hydrogen. R 5 is 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl,ndimethyl-l-pyrrolidino, 4-morpholino,ndimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino;nand n is 2 or 3; nor a pharmaceutically acceptable salt or solvate thereof. |