| abstract |
Powdery aggregate of 2-phenyl-1,5-benzothiazepin-3,4(2H,5H)-dionencompound:n nwherein Ring A and Ring B are benzene ring having optionally substituentnselected from lower alkyl, lower alkoxy and halogen, which is prepared bynadmixing solution of the compound (II) in polar organic solvent with solventnwhich does not substantially dissolve the compound (II) but is miscible withnsaid polar organic solvent, and separating and collecting the resultant particlesnof the compound (II). Said aggregate of the compound (II) can be convertedninto optically active 3-hydroxy-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-onencompounds (I) on industrial scale, which are useful as intermediatenfor various medicaments. |