| abstract |
The present invention relates to novel coumarin quinolone carboxylic acids whereinnthe pyridone system is fused in 3,4-, 6,7- and 7,8-positions of the coumarin system, ofnthe general formula In nwhereinn R 1 R 2 = -NHCH=C(CO 2 R 6 )CO-, R 3 = NO 2 or NH 2 , R 4 = R 5 = H, R 6 = H or C 2 H 5 ; R 1 R 2 = -NHCH=C(CO 2 R 6 )CO-, R 3 = R 4 = H, R 5 = F, R 6 = H or C 2 H 5 ; R 1 R 2 = -CO(CO 2 R 6 )C=CHNH-, R 3 = R 4 = R 5 = H, R 6 = H or C 2 H 5 ; R 1 R 2 = R 3 R 4 = -NHCH=C(CO 2 R 6 )CO-, R 5 = H, R 6 = H or C 2 H 5 ; R 1 = H or OH, R 2 = R 5 = H, R 3 R 4 = -NHCH=C(CO 2 R 6 )CO-, R 6 = H or C 2 H 5 ; R 1 = OH, R 2 = R 3 = H, R 4 R 5 =-CO(CO 2 R 6 )C=CHNH-, R 6 = H or C 2 H 5 ; R 1 = R 5 = H, R 2 = CH 3 or CF 3 , R 3 R 4 = -CO(CO 2 R 6 )C=CHNH-, R 6 = H or C 2 H 5 , nas well as pharmaceutically acceptable salts thereof. n The object of the invention are also processes for the preparation of novel coumarinnquinolone carboxylic acids and the biological action thereof. |