http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0820993-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b09f893b262cefd50c5e76c4b85d1c0a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-52 |
| filingDate | 1997-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20995ad6031663a11ae2d0362d2516d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38305f45ae606fc5f6117286b8b62a31 |
| publicationDate | 2003-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0820993-B1 |
| titleOfInvention | Process for the production of pyrazin-2-amines |
| abstract | Two processes (A) and (B) are claimed for the preparation of 3-alkoxy-5-alkyl-pyrazine-2-amine (I) of formula (I). In (A), (a) aminomalonic acid dinitrile of formula CN(NH2)(CN)2 (II) or its salt is reacted with a glyoxal oxime derivative of formula R1COCH=NOH (III) to form an oxypyrazine carbonitrile derivative of formula (IV); (b) (IV) is hydrolysed to form an oxypyrazinecarboxylic acid salt of formula (V); (c) (V) is halogenated to form a halopyrazine compound of formula (VI); (d) (VI) is mixed with an alcohol in the presence of a base or with an alcoholate to form a 3-alkoxy-5-alkyl-1-oxypyrazine-2-ylamine of formula (VII); and (e) (VII) is reduced to form (I). In (B), (f) amino acetonitrile of formula CH2NH2CN (VIII) is reacted with (III) in the presence of base to form the oxypyrazine of formula (IX); (g) (IX) is halogenated to (VI); and (VI is converted to (I) by steps (d) and (e). The compounds (V), (VI) and (VII) are new. R1 = 1-4C alkyl or aryl; R2 = 1-4C alkoxy or aryloxy; M = metal or ammonium; and X = halogen. |
| priorityDate | 1996-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.