abstract |
The present invention relates to compounds of formula (I), wherein R?1 and R4¿ represent hydrogen, halogen, C¿1-6?alkyl, C2-6alkenyl, C2-6alkynyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, C1-6alkoxy, C1-4alkyl substituted by a hydroxy or C1-4alkoxy group, OCF3, hydroxy, trifluoromethyl, trimethylsilyl, nitro, CN, SR?a, SORa, SO¿2R?a, CORa, CO¿2Ra or CONRaRb where R?a and Rb¿ are each independently hydrogen or C¿1-4?alkyl; R?2, R3 and R5¿ represent hydrogen, halogen, C¿1/6?alkyl, C1-6alkoxy substituted by a C1-4alkoxy group, or trifluoromethyl; R?6, R7 and R8¿ each independently represent hydrogen or a C¿1-4?alkyl group optionally substituted by a hydroxy group; and Het represents a 5- or 6-membered heterocyclic ring containing 2 or 3 nitrogen atoms optionally substituted by =O, =S or a C1-4alkyl group, and optionally substituted by a group of the formula ZNR?9R10¿. The compounds are of particular use in the treatment of pain, inflammation, migraine and emesis. |