http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0815084-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94ff2d78578d95d1e8d3a2233c76188d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-02 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 |
| filingDate | 1996-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d5cb1d40db4c91c062a2915649fe5a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7bc8acf5b2438cae071771a3acc0e2cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b35a19b8dc0567a12b6e3ddc70144e92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2534be605075fc355a115ad235630086 |
| publicationDate | 1998-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0815084-A1 |
| titleOfInvention | Lactam-containing hydroxamic acid derivatives, their preparation and their use as inhibitors of matrix metalloprotease |
| abstract | The present invention relates to compounds that exhibit inhibitory activity against matrix metalloproteases ('MMPs'). Because MMPs are known to play a role in tissue degradation, the compounds of the present invention may be useful in preventing or treating diseases associated with excess MMP activity. In particular, the compounds have a structure according to formula (I), wherein (A) (1) (a) R1 is hydrogen; alkyl; heteroalkyl; alkenyl; a heterocyclic ring; a carbocyclic ring; alkoxy; carbocycle-alkyl; heterocycle-alkyl; carbocycle-heteroalkyl; or heterocycle-heteroalkyl; and (b) R2 is hydrogen; hydroxy; alkyl; alkenyl; alkynyl; heteroalkyl; a heterocyclic ring; a carbocyclic ring; carbocycle-alkyl; heterocycle-alkyl; or -OR, where R is alkyl, alkenyl, or carbocycle-alkyl; or (2) R?1 and R2¿ together form a cycloalkyl ring having from 3 to 8 ring atoms; (B) R3 is hydrogen; alkyl; or carbocycle-alkyl; (C) R4 is: (1) alkyl; (2) carbocyle-alkyl; (3) -X-C(=Y)-Z-R5 or -X-CH¿2-Z-R?5, where (a) X is covalent bond or alkyl; (b) Y is O, S, or NH; (c) Z is O, S, or NH; and (d) R5 is hydrogen; alkyl; alkenyl; carbocycle-alkyl; or aryl; or (4) -SO¿2-R?6, where R6 is alkyl, carbocycle-alkyl, heterocycle-alkyl, or aryl; and (D) Q is -[-C(R7)2-]-n, where (1) n is the integer 2, 3, or 4; and (2) each R7 is independently hydrogen or alkyl so the Q-containing heterocycle is saturated; or the R7 moiety on two adjacent carbon atoms is a covalent bond such that the Q-containing heterocycle in Formula (I) is unsaturated; or a pharmaceutically-acceptable salt; or biohydrolyzable alkoxyamide, acyloxyamide, or imide thereof. The invention also relates to pharmaceutical compositions comprising these compounds, and methods for preventing or treating diseases associated with unwanted MMP activity using the compounds and compositions. |
| priorityDate | 1995-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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