| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c125e188a07ee8541b6a94715bc9baa8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-3382
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-3616
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-3306
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-3693
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2202-0429
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-3673
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-3606 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-3692
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G05D23-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-3616
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N13-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-3687
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-3693
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M1-3623 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M1-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N13-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M3-00 |
| filingDate |
1996-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce5d83322c64087b054d71018df11885
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69c7d6852f38988274e7bfd2f6bb711a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a51a07d8f77f140d99671db4126993e9 |
| publicationDate |
2002-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0814855-A4 |
| titleOfInvention |
FLOW ELECTROPORATION CHAMBER AND ASSOCIATED METHOD |
| abstract |
The present invention relates to a method and apparatus for the encapsulation of biologically-active substances in red blood cells, characterized by an optionally automated, continuous-flow, self-contained electroporation system (5) which allows withdrawal of blood from a patient, separation of red blood cells, and optional recombination of blood plasma and the modified red blood cells thereby producing blood with modified biological characteristics. The present invention is particularly suited for use to encapsulate allosteric effectors of hemoglobin, thereby reducing the affinity of erythrocytes for oxygen and improving the release of oxygen from erythrocytes in tissues. The blood is introduced into the system (5) at inlet (11) and mixed with an anticoagulant (27). The blood and anticoagulant mixture is passed through a filter (18) and to a blood separation and wash bowl (44). Plasma and white blood cells are admitted into the plasma reservoir (89) while the red blood cells are retained in the wash bowl (44). The separated red blood cells are pumped out and admixed at junction (67) withan IHP solution from reservoir (50). This mixture is cooled by cooling coil (68) and then pumped to electroporation chamber (72) for treatment. |
| priorityDate |
1995-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |