| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e2a5bb0437c9d85166aaa02b38767498 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-74 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N11-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0012 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N11-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N11-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-39
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 |
| filingDate |
1996-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bbf9caa3323cdb91e80ee957b9ab008b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2324560d1c6136cfc1ecdd953fec53ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_452c3a58354eb47bd1e3d470c741bc5e |
| publicationDate |
1997-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0813365-A1 |
| titleOfInvention |
Immunoisolation |
| abstract |
Living cells that produce a therapeutic substance are immunoisolated by preparing a composite microreactor (10) containing internal particles (20) containing cells (30). The cells are embedded in matrix (40) which optionally contains coating (50). The internal particles are embedded in matrix (60) to form the composite microreactor which optionally has outer coating (70). The matrices and coatings are made immunoisolative by controlling porosity to exclude large molecules. The composite microreactor may be embedded in a matrix to form a double composite microreactor which optionally has an outer coating. The composite microreactor may be prepared by gelling alginate droplets containing cells with calcium ions to form the internal particles and then mixing the internal particles with alginate to form spheres that are the composite microreactor. The double composite microreactor is formed by mixing the composite microreactor with alginate and forming larger spheres. |
| priorityDate |
1995-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |