| abstract |
The invention relates to enantiomerically enriched malonic acid monoesters which are α-monosubstituted by a tertiary hydrocarbon radical or their salts of the general formula I: in which R 1 , R 3 , R 4 and R 5 are identical or different hydrocarbon radicals, two of the radicals R 3 , R 4 and R 5 together with the quaternary carbon atom which they substitute can also form a carbocyclic ring and M is hydrogen , a metal equivalent or an optionally substituted ammonium ion. The invention further relates to a process for the preparation of the enantiomerically enriched α-monosubstituted malonic acid monoesters or their salts by partial enzymatic hydrolysis of the corresponding diesters. |