| abstract |
The invention relates an epoxysuccinamide derivative represented by the general formula (1)n wherein R 1 and R 2 are the same or different from each other and independently represent H or an aromatic hydrocarbon group or aralkyl group which may be substituted, or R 1 and R 2 may form a nitrogen-containing heterocyclic ring together with the adjacent nitrogen atoms, R 3 is H or an acyl group, R 4 is H or an aralkyl group, and R 5 is an aromatic hydrocarbon group or aralkyl group which may be substituted, or R 5 may form an amino acid residue, which may be protected, together with the adjacent nitrogen atom, or a salt thereof, and a medicine comprising the derivative as an active ingredient. n This compound has an inhibiting activity against cathepsin, and particularly, specifically inhibits cathepsin L and is hence useful for prevention and treatment of osteopathy such as osteoporosis. |