http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0808832-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C401-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C401-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 |
| filingDate | 1997-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3bf8277249b012830d21d12da3f2033 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5dcf6262dde45278959fd0be4771505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02061a6251de9d947ad7dc35313af92e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9158711fb8bc3af73c36784c761af470 |
| publicationDate | 1997-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0808832-A2 |
| titleOfInvention | Fluorinated vitamin D3 analogs |
| abstract | The novel fluorinated Vitamin D 3 analogs of formulan wherein:n X is (H,H) or =CH 2 ; R 1 and R2 are, independently of each other, hydrogen, (C 1 -C 4 ) alkyl or fluoroalkyl, or R 1 and R 2 together with C-20 form a (C 3 -C 6 ) cycloalkyl or cyclofluoroalkyl, or R 1 and R 2 together form =CH 2 ; R 3 and R 4 are, independently of each other, a (C 1 -C 4 ) alkyl or fluoroalkyl, or R 3 and R 4 together with C-25 form a (C 3 -C 9 ) cycloalkyl or cyclofluoroalkyl; A is a single bond or a double bond; and B is a double bond or a triple bond; nexcept that:n (i) when X is =CH 2 , R 3 and R 4 are each CF 3 , A is a double bond and one of R 1 or R 2 is hydrogen, then the other of R 1 or R 2 cannot be CH 3 ; (ii) when X is =CH 2 , R 3 and R 4 are each a (C 1 -C 2 ) alkyl, A is a double bond and R 2 is hydrogen, then R 1 cannot be CH 3 ; (iii) when X is =CH 2 , R 3 and R 4 are each a (C 1 -C 4 ) alkyl, A is a double bond and R 1 is hydrogen, then R 2 cannot be CH 3 ; (iv) when X is =CH 2 , one of R 3 or R 4 is a CF 3 , A is a double bond, R 1 is CH 3 and R 2 is hydrogen, then the other of R 3 or R 4 cannot be CH 3 ; and (v) when X is (H,H), R 3 and R 4 are each CF 3 , A is a double bond, B is a triple bond and R 2 is hydrogen, then R 1 cannot be CH 3 , and the compounds of the above formula I wherein: X is (H,H) or =CH 2 ; R 1 and R2 are, independently of each other, hydrogen, (C 1 -C 4 ) alkyl or fluoroalkyl, or R 1 and R 2 together with C-20 form a (C 3 -C 6 ) cycloalkyl or cyclofluoroalkyl, or R 1 and R 2 together form =CH 2 ; R 3 and R 4 are, independently of each other, a (C 1 -C 4 ) alkyl or fluoroalkyl, or R 3 and R 4 together with C-25 form a (C 3 -C 9 ) cycloalkyl or cyclofluoroalkyl; A is a single bond or a double bond; and B is a double bond or a triple bond; except that where R 3 and R 4 are each CF 3 and A is a double bond and B is a triple bond and R 2 is hydrogen, then R 1 cannot be CH 3 , nare useful in the treatment of osteoporosis. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0213832-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103180293-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7332482-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7115758-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9006220-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9079843-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1797033-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03027065-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1797033-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6008209-A |
| priorityDate | 1996-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 328.