http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0807639-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_11b1e2be15b8045832deb23347e87e06 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-63 |
| filingDate | 1997-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2000-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6194da85f0ab6be9bafb1dbc05915726 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00ed0b5bad3cc7e2f3714d4e0f7927e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fcfefc0a018f798871dd74a7ced4f595 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d53a3cd41067c58a01816ac7379acdc9 |
| publicationDate | 2000-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0807639-B1 |
| titleOfInvention | Cyclic motilin-like polypeptides with gastrointestinal motor stimulating activity |
| abstract | This invention pertains to cyclic polypeptides having gastrointestinal motor stimulating activity which may be represented by formula (1): <CHEM> including optically active isomeric forms and the pharmaceutically acceptable acid addition salts thereof, wherein groups A and D are linked to from a cyclic structure; and R1 is lower alkyl; R2 is hydrogen or lower alkyl; R3 is hydrogen or lower alkyl; R4 is phenyl or substituted phenyl, wherein the phenyl group may be substituted with one or more substituents selected from the group consisting of halogen, hydroxy, and lower alkoxy; R5 is -OH or -NH2; A is selected from the group consisting of L-glutamic acid, L-aspartic acid, L-lysine, L-ornithine, and L-2,4-diaminobutyric acid; B is L-alanine or L-glutamine; C is L-arginine or D-arginine; D is selected from the group consisting of L-lysine, L-ornithine, L-2,4-diaminobutyric acid, L-glutamic acid, and L-aspartic acid; E is a direct bond between group D and group R5 or is L-lysine or D-lysine; m is 0 or 1; the symbol * represents an asymmetric carbon atom which may be in the D or L configuration, with the proviso that: (a) when A is L-glutamic acid or L-aspartic acid, D is L-lysine, L-ornithine, or L-2,4-diaminobutyric acid; and (b) when A is L-lysine, L-ornithine, or L-2,4-diaminobutyric acid, D is L-glutamic acid or L-aspartic acid. This invention also pertains to methods for using the novel cyclic polypeptides. |
| priorityDate | 1996-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 141.