| abstract |
Vitamin D derivatives of formula (I), wherein: X is =CH2 or H,H; Y is a moiety (a) -CH(CH3)-(A)n-C(O)-OR1, (b) -CH(CH¿3?)-CH2-O-C(O)-R?2¿ or (c) -C(O)-OR1; A is -CH=CH- or CH¿2?-CH2-; R?1¿ is lower alkyl, cycloalkyl, cycloalkylmethyl, -CH¿2R?3 or -CH¿2?-CH2R?3; R2¿ is lower alkyl, cycloalkyl or R3; R3 is hydroxy-lower alkyl, hydroxy-cycloalkyl or trifluoromethyl-hydroxy-nieder-alkyl; n is 0 or 1; and the dotted bond in the five-membered ring is optional; can be used in the treatment of dermatological conditions, in particular keratinization disorders. |