| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b5d728d4890268356fcc07e6e53840c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-795
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-746
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-773
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-926
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-927
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-915
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-928
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-89
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-847
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S977-897 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 |
| filingDate |
1995-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2001-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_150ede19130932c1f236f214fa3ec3e8 |
| publicationDate |
2001-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0804162-B1 |
| titleOfInvention |
Butylene oxide-ethylene oxide block copolymer surfactants as stabilizer coatings for nanocrystal formulation |
| abstract |
This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a nonionic polymeric surfactant as a surface modifier adsorbed on the surface thereof, the surfactant being a block copolymer of ethylene oxide and butylene oxide and a method of making such nanoparticles. The compositions exhibit reduced macrophage uptake and improved toxicological profiles and facilitate particle size reduction such that milling time can be reduced and/or sterile filtration of the nanoparticles can be accomplished. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6607784-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6835396-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8263131-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8426467-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8722091-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8722736-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8067032-B2 |
| priorityDate |
1994-06-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |