| abstract |
This invention provides a taxane derivative of formula (I), wherein a hydrophobic organic moiety is attached to a taxane. R and R<1> is each independently H or a hydrophobic organic moiety, as long as at least one of R and R<1> is not H. Attachment of a hydrophobic organic moiety to the taxane so as to obtain a taxane derivative generally stabilizes the association of the derivative with a lipid, including a liposomal lipid, carrier in the plasma of animals to which the derivative-carrier association is administered. Also provided herein is a composition containing the taxane derivative and a pharmaceutically acceptable medium; desirably, the medium also contains a lipid carrier, and the derivative is associated with the carrier. Further provided herein is a method of administering taxane derivatives to animals, for example, animals afflicted with cancers. <IMAGE> |