| abstract |
An antifungal compound of formula (I):n or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of either entity, wherein X is CH or N; R 1 is phenyl subsituted with 1 to 3 substituents each independently selected from halo and CF 3 ; R 2 is (hydroxy)C 1 -C 4 alkyl, CONH 2 , S(O) m (C 1 -C 4 alkyl), Ar or Het; m is 1 or 2; Ar is phenyl optionally monosubstituted with halo or CF 3 ; and Het is a C-linked 6-membered nitrogen-containing aromatic heterocyclic group containing 1 or 2 nitrogen atoms, or a C- or N-linked 5-membered nitrogen-containing aromatic heterocyclic group containing from 2 to 4 nitrogen atoms, wherein either of said heterocyclic groups is optionally substituted with C 1 -C 4 alkyl or (C 1 -C 4 alkoxy)methyl. |