http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0793497-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6809 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-044 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-08 |
| filingDate | 1995-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2003-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e8bcf1e531b03bb3c3c4df0c348b8ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98d5aee8cc7dd69912b805ca0f3205c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccac56fcb6fbb080789b0621f5594b55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ad1ae312721441bb905d45cdab5365e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_68b7bcd79a9ab83862429dc88bb1c148 |
| publicationDate | 2003-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0793497-B1 |
| titleOfInvention | Novel enediyne quinone imines and methods of preparation and use thereof |
| abstract | A quinone imine enediyne possessing cytotoxic activity towards cancer cells having the general structure: <IMAGE> wherein R1, R2 and R3 are independently the same or different and are H, Br, Cl, F, NH2, CO2H, or OH or a linear or branched alkyl, etc.; wherein R4 is H, OH or a linear or branched alkoxy, linear or branched alkoxycarbonyl, etc.; wherein R5 is H, Br, Cl, F, O=, OH or S-SR, or a linear or branched alkyl, etc.; wherein R6 is H, Br, Cl, F, CO2H, OH or S-SR', or a linear or branched alkyl, etc; wherein R7 is H, OH or S-SR'', or a linear or branched alkyl, linear or branched alkoxycarbonyl, linear or branched alkoxy or linear or branched hydroxyalkyl group; and wherein R, R' and R'' are independently the same or different and are a linear or branched alkyl, linear or branched acyl or linear or branched alkoxyalkyl group. Also provided are conjugates of the compound with cleavable peptides and carbohydrates, monoclonal antibodies immunoreactive with cancer cells, compositions comprising the analogues and conjugates, methods of treating tumors and a method of preparing the analogues. |
| priorityDate | 1994-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 355.