| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_123b8573a4d56eda344c4160d46d27b1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-37 |
| filingDate |
1995-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac8ece6128bc90ac3bb564b9cae6bae4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e05a951b530d3846b5876f1ada9f198
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ef08fcce1ee4f8c98eabf0f818c0951
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_978cd8668b4e026bd98868d113f5d936
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a086e51822c9c158a8e976d4261dfa50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_700d0203f26d3bc4dd5aa01befd79b35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37962311997acf06984df2d42df43398
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f09ca73dc2374340d329b81e9624fed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4dd1c53800e94eb35b3419dc831a7dde |
| publicationDate |
1997-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0787184-A1 |
| titleOfInvention |
Recombinant alternaria alternata allergens |
| abstract |
The invention relates to the complete cDNA sequences of the Alternaria alternata allergenes Alt a 45 and Alt a 12. It has been possible in the course of molecular biological analysis of the allergens to identify Alt a 45 as a protein-disulphide isomerase. This protein is a 45 kD large protein to which 47 % of patients react and is thus an important primary allergen. Alt a 12 (to which 8 % of patients react) was identified as a ribosomal protein which is of interest because auto-antibodies for ribosomal proteins are found in patients suffering from lupus. It remains to be seen whether there is any connection between allergy to mould fungus and autoimmune diseases. Using this recombinant sequence and computer analysis, it has been possible to identify highly potent B- and T-cell epitopes and to use the peptides derived from the recombinant proteins for diagnosis of an allergy to Alternaria alternata mould fungus. The peptides has also proved suitable for both in vitro and in vivo allergen-specific stimulation of T-cells (proliferation, interleukin production), and for blocking the T-cells resulting in a tolerance of the allergen-specific T-lymphocytes. |
| priorityDate |
1994-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |