| abstract |
An azole derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, having both of a leukotriene antagonistic effect and a thromboxane A2 antagonistic effect and being useful in preventing or treating allergic diseases, ischemic heart diseases or ischemic brain diseases, and a medicinal composition containing the same as the active ingredient, wherein R<1> and R<2> may be the same or different and represent each hydrogen, cycloalkyl, etc., or R<1> and R<2> together with (a) may form a fused ring (b) or (c) which may be substituted by optionally substituted lower alkyl, amino, etc.; R<3>, R<6>, R<7>, R<8> may be the same or different and represent each hydrogen, amino, etc.; R<4> represents cyano, tetrazolyl, -COOR<9>, etc.; R<5> represents hydrogen or lower alkyl; D represents optionally substituted lower alkylene; X and Z may be the same or different and represent each oxygen or sulfur; Y represents -N= or -CH=; A represents -O-B-, -B-O-, -S-B-, -B-S- or -B-(B being lower alkylene or lower alkenylene); and n is 0, 1, or 2. <CHEM> |