| abstract |
A protein that binds CD2, which is a derivative of a soluble LFA-3 polypeptide, the derivative being an immunoglobulin fusion comprising the soluble LFA-3 polypeptide fused to an immunoglobulin region, or being the soluble LFA-3 polypeptide linked to a pharmaceutical agent, is used in the preparation of a medicament for use in a method of improving tolerance of transplanted allograft tissue or xenograft tissue in a mammal, including a human, wherein the method comprises implanting in the mammal an allograft or a xenograft and administering the protein. |