| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c32775641a2462e0c791af0b9b077e08 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-962
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S436-815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T428-2991 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54313 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543 |
| filingDate |
1996-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2003-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_453b058fc5f2a8fa9184749b01c9faac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49ece9ed6c4e1c0a3e29440e8ebe7048 |
| publicationDate |
2003-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0784795-B1 |
| titleOfInvention |
Post synthesis chemical modification of particle reagents |
| abstract |
A method is provided for enhancing the stability and increasing the activity of polymer particle reagents by incubating a polymer particle which has been covalently bound to a compound of biological interest, such as a drug, with a modifying agent that will place a negative charge on the surface of the polymer particle and reduce residual functional groups. The modifying agent is preferably an anionic nucleophile selected from the group consisting of beta - mercaptoacetic acid and the thiosulfates. |
| priorityDate |
1995-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |