| abstract |
The present invention relates to benzofuran derivatives of formula (I) wherein R represents a hydrogen atom or a C1-4alkoxy group; R1 is selected from phenyl, optionally substituted by a group -(CH¿2?)nCONR?3R4¿ or S(O)¿mR?3; or a 5- or 6-membered aromatic heterocycle containing 1, 2, 3 or 4 heteroatoms selected from oxygen, nitrogen or sulphur, optionally substituted by a C¿1-4?alkyl trifluoromethyl or cyano group or a group -(CH2)nCONR?3R4; R2¿ represents a hydrogen or halogen atom; R?3 and R4¿ independently represent hydrogen or C¿1-4?alkyl; n represents zero, 1, or 2; m represents zero, 1 or 2; x represents zero or 1; and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation; and their use in the treatment of conditions mediated by tachykinins. |