http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0781775-A3
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
filingDate | 1996-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09776a94352ab9ed892a9e4e53e706a1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdfa7800f41a952ed7275073d6813b9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5349a605463c929a65d083dcd10fe1c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7f943934d10e31d143d1ea95758173c |
publicationDate | 1998-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | EP-0781775-A3 |
titleOfInvention | Process for producing 1-hydroxythienoimidazole carboxylic acid and thienoimidazole carboxylic acid |
abstract | A process for producing 1-hydroxythienoimidazole carboxylic acid represented by formula (2): <CHEM> wherein R<1> and R<2> are as defined in the specification; wherein said process comprises the steps of: (a) reacting thienoimidazole represented by formula (1) with 1,4-dihalogenodimagnesium butane, in the presence of tetrahydrofuran or a mixed solvent comprising tetrahydrofuran and an aromatic solvent to produce a reaction mixture: <CHEM> wherein R<1> and R<2> are as defined above; (b) adding the reaction mixture obtained in said step (a) and, optionally, carbon dioxide, to: (i) a solution comprising carbon dioxide and tetrahydrofuran, or (ii) a solution comprising carbon dioxide, tetrahydrofuran and an aromatic solvent to give a reaction liquid; and (c) hydrolyzing said reaction liquid. Alternatively, a process for producing 1-hydroxythienoimidazole carboxylic acid represented by formula (2), wherein the process comprises the steps of: (a) reacting a thienoimidazole represented by formula (1) with 1,4-dihalogenodimagnesium butane, in the presence of tetrahydrofuran or a mixed solvent comprising tetrahydrofuran and an aromatic solvent to produce a reaction mixture, and wherein the thienoimidazole represented by formula (1) is added to the 1,4-dihalogenodimagnesium butane either solely or in cake state or slurry state, wherein the cake state and slurry state are made by adding a small amount of either tetrahydrofuran or a mixed solvent comprising tetrahydrofuran and an aromatic solvent; (b) reacting the reaction mixture obtained in step (a) with carbon dioxide to produce a reaction liquid; and (c) hydrolyzing the reaction liquid. Additionally, a process of producing thienoimidazole carboxylic acid represented by formula (3): <CHEM> wherein R<1> and R<2> are as defined above utilizing the above processes. |
priorityDate | 1995-12-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.