http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0780375-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-56 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-56 |
| filingDate | 1996-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f62a1ded1654792407f8cb47c706ed6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31ef63e321041afce358bb2b88220942 |
| publicationDate | 1997-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0780375-A1 |
| titleOfInvention | 3-((5-substituted benzyl)amino)-2-phenylpiperidines as substance p antagonists |
| abstract | This invention provides a compound of the formula:n and its pharmaceutically acceptable salts, wherein nāāāR' is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, halo C 1 -C 6 alkyl or tetrahydropyranyl, having one or more substituents selected from cyano, 1,3-thiazolanyl, COOR 2 , COR 2 , OCOR 2 , CONR 3 R 4 , NR 3 R 4 , NR 5 COR 3 and C ā” CR 6 , wherein R 2 is hydrogen or C 1 -C 4 alkyl, R 3 and R 4 are independently hydrogen, C 1 -C 4 alkyl or C 3 -C 6 cycloalkyl, R 5 is C 1 -C 4 alkyl or C 3 -C 6 cycloalkyl and R 6 is hydrogen, halo, cyano, C 1 -C 6 alkyl, COOH, COO(C 1 -C 4 alkyl) or phenyl; X is C 1 -C 6 alkoxy or halo C 1 -C 6 alkoxy; and Ar is phenyl optionally substituted with halo. n These compounds are useful in the treatment of allergic disorders, angiogenesis, gastrointestinal disorders, central nervous system disorders, inflammatory diseases, emesis, urinary incontinence, pain, migraine, sunburn, and diseases, disorders and adverse conditions caused by Helicobacter pylori, in a mammalian subject. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1323713-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9900368-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7067535-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1323713-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6214846-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-736542-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-0068224-A1 |
| priorityDate | 1995-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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