| abstract |
The invention pertains to an oligonucleotide characterized in that a transesterification or hydrolysis catalyst is bonded to the oligonucleotide, the inner sequence of the oligonucleotide is partially noncomplementary to a naturally occurring target RNA, and the oligonucleotide is composed of deoxyribonucleic acid units, unnatural synthetic nucleotide units or peptide nucleic acids. The oligonucleotides are extremely well suited for splitting a complementary target RNA, the oligonucleotide being released again after the splitting, thus showing a catalytic effect. |