http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0777659-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1c89ce4d9ac03f9acd8ddede1162f94d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-1804 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 |
| filingDate | 1995-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eebc0af235331150def825a52c3a8004 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_23d4deddb70e3d10d4f7bd2434a1c689 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_daca9f6f83d0474306eebb742f51823b |
| publicationDate | 2001-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0777659-B1 |
| titleOfInvention | Morpholine derivatives and their use as therapeutic agents |
| abstract | PCT No. PCT/GB95/01868 Sec. 371 Date Feb. 13, 1997 Sec. 102(e) Date Feb. 13, 1997 PCT Filed Aug. 7, 1995 PCT Pub. No. WO96/05181 PCT Pub. Date Feb. 22, 1996The present invention relates to compounds of formula (I) <IMAGE> (I) wherein X is -NR6R7 or C- or N-linked imidazolyl; Y is hydrogen or C1-4alkyl optionally substituted by hydroxy; R1, R2, R3, R4 and R5 are selected from a variety of suitable aromatic substituents; R6 is hydrogen, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkylC1-4alkyl, phenyl, or C2-4alkyl substituted by C1-4alkoxy or hydroxy; R7 is hydrogen, C1-6alkyl, C3-7cycloalkyl, C3-7cycloalkyl C1-4alkyl, phenyl, or C2-4alkyl substituted by one or two of C1-4alkoxy, hydroxy or a 4, 5 or 6 membered heteroaliphatic ring containing one or two heteroatoms selected from N, O and S; or NR6R7 is a saturated or partially saturated heterocyclic ring of 4 to 7 ring atoms, optionally containing one of O, S, NR8, S(O) or S(O)2 and optionally substituted by one or two of hydroxy1-4alkyl, C1-4alkoxy C1-4alkyl, oxo, CORa or CO2Ra; or NR6R7 forms a non-aromatic azabicyclic ring system of 6 to 12 ring atoms; and R9a and R9b are each independently hydrogen or C1-4alkyl, or R9a and R9b are joined so, together with the carbon atoms to which they are attached, there is formed a C5-7ring; or a pharmaceutically acceptable salt thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and postherpetic neuralgia. |
| priorityDate | 1994-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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