| abstract |
[Object] n This invention provides a long-lasting release solid nifedipine preparation which exhibits clinically sufficient effect when administered once per day. n [Construction] n A press coated tablet whose core and shell each contains nifedipine, the dissolution rate of nifedipine from said tablet beingn (a) in the dissolution test using a sinker according to method 2 of the dissolution test method as prescribed by the Pharmacopoeia of Japan,n after 2 hours 10-40% after 4 hours 30-65% after 6 hours at least 55%, and (b) in the dissolution test according to the disintegration test method as prescribed by the Pharmacopoeia of Japan,n after 3 hours 20-45% after 4 hours 30-65%. |