http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0772591-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da54f7ebbd2d9d8a82f92aca4d1b4e48 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-12 |
| filingDate | 1995-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9577adb17b146c9d077efe3716d120f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_10f0679db6c82933314f909b3ba56d61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0089373ac6e36bc270e77b7e3997dd1d |
| publicationDate | 1997-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0772591-A1 |
| titleOfInvention | 2-phenyl indoles as anti-oestrogen drugs |
| abstract | Novel 2-phenyl indoles are disclosed of general formula (I), wherein: R<1> represents one of the rests -(CH2)n-S(O)m-R<4>, -(CH2)n-NR<6>-SO2-R<4>, (a), and n' being integers between 4 and 12 and m and m' are 0, 1 or 2; X represents a methylene group, an imino group = NR<6>, or an oxygen or sulphur atom; R<2> and R<3> independently of one another represent a hydrogen atom, a C1-C10 alkyl group, a benzyl, alkanoyl or alkanoyloxy, or carbamoyl rest of formula -C(O)R<5> or -C(O)NR<6>R<7> or a tetrahydropyranyl group; R<4> represents a hydrogen atom, a C1-C10 alkyl, a completely or partially fluorinated alkyl group -(CH2)o-(CF2)pCF3, o and p being independently of one another integers between 0 and 6, an (alkyl)amino or (alkyl)carbamoyl group of formula (CH2)q-Y-NR<8>R<9>, q being an integer between 0 and 6 and Y representing a direct bond, a methylene or carbamoyl group (a condition being that q cannot be 0 when Y is a carbonyl group and m is 2), an aryl, aralkyl or heteroaryl group; R<5> represents a C1-C10 alkyl group or a C1-C10 alkoxy group, a phenyl or benzyl group; R<6>, R<7>, R<8> and R<9> independently of one another represent a hydrogen atom, a C1-C10 alkyl group, or a benzyl group; and R<10> represents a methyl group and R<11> represents a hydrogen atom, or R<10> and R<11> both represent a di-, tri- or tetramethylene bridge which can also have a C-C double bond at any location in the bridge. These novel compounds have strong and selective anti-oestrogen properties and are suitable for use in particular in the treatment of oestrogen-related diseases. |
| priorityDate | 1994-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 393.