| abstract |
An oxygen-containing heterocyclic compound represented by following Formula (I):n wherein R 1 and R 2 independently represent hydrogen, lower alkyl, cyano, -(CH 2 ) n -E-CO-F (wherein E represents a bond, O, or NH; F represents OR 6 or NR 7 R 8 ; and n represents an integer of 0 to 4), or the like; R 1 and R 2 are combined to represent a saturated carbon ring together with a carbon atom adjacent thereto; or R 2 , and R 11 or R 13 described below are combined to form a single bond; R 3 represents hydrogen, phenyl, or halogen; R 4 represents hydroxy, lower alkoxy, or the like; A represents -C(R 9 )(R 10 )- or O; B represents O, NR 11 , -C(R 12 )(R 13 )-, or -C(R 14 )(R 15 )-C(R 16 )(R 17 )-; D represents (i) -C(R 18 )(R 19 )-X- (wherein X represents -C(R 21 )(R 22 )-, S, or NR 23 ), (ii) -C(R 19a )=Y- [Y represents -C(R 24 )-Z- (wherein Z represents CONH, CONHCH 2 , or a bond), or N], or (iii) a bond; and R 5 represents aryl, an aromatic heterocyclic group, cycloalkyl, pyridine-N-oxide, cyano, or lower alkoxycarbonyl; or a pharmaceutically acceptable salt thereof. |