| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_35435eec2acab8221f5b1a9fba78d996 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-21073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-655
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6462
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-815 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-655
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-815
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-72 |
| filingDate |
1995-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_97a3a775f4e892896c03c182b840b115 |
| publicationDate |
1997-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0771211-A4 |
| titleOfInvention |
PREPARATIONS AND METHODS FOR THE ADMINISTRATION OF MEDICINAL PRODUCTS BY BLOOD PLATE FOR TREATING CARDIOVASCULAR DISEASES |
| abstract |
A fusion drug including an isolated portion of the A-chain of a urokinase-type plasminogen activator linked to a drug, wherein the A-chain portion binds stably to an outer membrane of a platelet. The figure shows the primary sequence of urokinase, including the A-chain. The half-life of the fusion drug in plasma is thereby increased to about 4 to 5 days, and the fusion drug is automatically targeted to forming thrombi and sites of vascular injury. The fusion drug can thus be used to treat cardiovascular diseases, e.g., as adjunctive therapy to inhibit reocclusions in a patient after thrombolytic therapy or angioplasty. |
| priorityDate |
1994-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |