| abstract |
The invention is concerned with the compounds having formula (I), the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y is CH or N; R?1, R2 and R3¿ each independently are hydrogen or C¿1-4?alkyl; R?4 and R5¿ each independently are hydrogen, halo, C¿1-4?alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; R?6¿ is pyridinyl optionally substituted with up to two C¿1-4?alkyl groups; di(C1-4alkyl)hydroxypyridinyl; di(C1-4alkyl)C1-4alkyloxypyridinyl; pyridazinyl optionally substituted with C1-4alkyloxy; pyrimidinyl optionally substituted with hydroxy or C1-4alkyloxy; thiazolyl optionally substituted with C1-4alkyl; thiadiazolyl optionally substituted with C1-4alkyl; benzoxazolyl or benzothiazolyl; or R?6¿ is pyrazinyl or pyridazinyl substituted with C¿1-4?alkyl; Z is C=O or CHOH; and (a) is a radical of formula (a-1), (a-2), (a-3), (a-4), (a-5), (a-6), or (a-7). Compositions comprising said compounds, processes for preparing the same and the use of these compounds as a medicine. |