| abstract |
Sulfonamide derivatives of the formula (I)n wherein R 1 is, inter alia, alkyl, alkoxy, hydroxy, keto, nitro, halogen, trihalomethyl, cyano, amidino and -COOR 7 (in which R 7 is hydrogen or alkyl), nn is an integer from 0 to 5;n is a carbocyclic ring or heterocyclic ring;n in which R 2 and R 3 each is hydrogen, alkyl, alkoxy, halogen, trihalomethyl or phenyl, or nR 2 and R 3 , taken together, represent alkylidene, orn in which R 2 and R 3 , taken together with the carbon atom to which they are attached represent cycloalkyl; nR 4 is alkyl or alkoxy or two of R 4 , attached to the benzene nucleus at ortho positions relative to each other, taken together, represent alkylene; m is an integer from 0 to 4; andn is optionally substituted amino or a nitrogen-containing ring, are described as new pharmaceutical compounds having inhibitory activity or elastase. |