| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c26895e1df2ffdb5a7a07dc40911694c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-52 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-475 |
| filingDate |
1995-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea831a2191c2b9293e3c3a830b79e65a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84bc5e4b5fcbec948e2ce53c28f31d21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9ab3c9c4a7acbaeec0407834c90ecf6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_382242a090b36644b1c8ef1a7162a708 |
| publicationDate |
1997-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
EP-0769055-A1 |
| titleOfInvention |
Variants of leukemia inhibitory factor |
| abstract |
The invention provides proteins which are variants of human Leukemia Inhibitory Factor (hLIF) with altered binding affinities to the LIF receptor and to the gp130 receptor. Such proteins include hLIF which has been altered by substitution at, insertion into, or deletion within a portion of said sequence such that the affinity for the LIF receptor is lowered compared to LIF, or a fragment of said protein which contains said alteration. Such proteins also include hLIF which has been altered by substitution at, insertion into, or deletion within a portion of said sequence such that the affinity for the gp130 receptor is lowered compared to LIF, or a fragment of said protein which contains said alteration. |
| priorityDate |
1994-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |