| abstract |
Naphthalene derivatives represented by formula ÄIÜ: <CHEM> (wherein A is a hydrogen atom, a hydroxy group, a C7-C11 aralkyloxy group, or an alkoxy group composed of an oxy group and a C1-C12 aliphatic or alicyclic, saturated or unsaturated hydrocarbon group where the alkyl may be substituted with a C6-C10 allyloxy group; B represents O, S, CH2, O-CH2, S-CH2, CO, or CHOR<1>; C represents CO, CR<2>R<3>CO, CH2CH2CO, or CH=CHCO; D represents a hydrogen atom, NO2, NH2, CO2R<4>, or a group having the following formula ÄIIÜ: <CHEM> (wherein G represents a hydrogen atom, OH, SO2NH2, CO2R<6>, CN, or a tetrazol-5-yl group); E represents a hydrogen atom, OH, SO2NH2, CO2R<5>, CN, or a tetrazol-5-yl group; F represents a hydrogen atom, a C1-C4 lower alkyl group, a nitro group , or a halogen atom; and R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are, independently each other, a hydrogen atom or a C1-C4 lower alkyl group); pharmacologically acceptable salts thereof, or pharmacologically acceptable solvates thereof, which have, for example, an inhibitory effect on the production of IgE antibodies, and will be useful for prophylaxis and/or treatment of allergic diseases. |