| abstract |
Compounds of formula (I) in which W is -(CH2)4, (CH2)5, -(CH2)2O(CH2)2 or -(CH2)2S(CH2)2, n is 0 to 6; m is 0 to 3; A is a bond, -CH=CH-, -C C-, oxygen, sulphur or NR1; R1 is hydrogen, C¿1-8?alkyl or phenylC1-4alkyl; and Ar is a group (a) where X is -SO2- or -C(CH3)2-, Y and Z may each be hydrogen, fluorine, chlorine, bromine, C1-4alkyl, C1-4alkoxy or trifluoromethyl; and salts thereof are calcium channel antagonists with activity in neurons and are useful in the treatment of conditions such as ischaemic stroke. |