http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0761681-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 1996-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f40340ec823479092c2f6ccec01968e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c187050e952d66c07bd2be64a57bfa72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_290483992892ebe068bb942190272f57 |
| publicationDate | 1997-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0761681-A3 |
| titleOfInvention | Process for the preparation of substituted N-ethyl-glycine derivatives |
| abstract | Prepn. of N-ethyl-glycine derivs. of formula PG-X-CH2CH2-N(CO-B)-CH2COOH (I) or their salts, comprises: (a) reacting protected amino acid derivs. of formula RX-CH2CH2-NH-CH2COOR1 (II) with nucleo-base-acetic acid deriv. of formula B-CH2COOH (III) at 0-45 degrees C in a suitable solvent, and in the presence of a standard peptide coupling agent to give a cpd. of formula RX-CH2CH2-N(COCH2B)CH2COOR1 (IV); (b) removing the acid-labile ester protecting gp. from (IV) (where X = NH the protecting gp. R is also removed) under acid conditions in soln., opt. with addn. of a cation scavenger to give a cpd. of formula HX-CH2CH2N(COCH2B)CH2COOH (V) (when X = O, (IV) may also be treated with a base in an aq. medium); (c) reacting (V) with the appropriate reagent in soln. and in the presence of a base to give (I), and opt. converting to its salt. PG = amino protecting gp. labile in the presence of a weak acid of the urethane or trityl types; X = NH or O; B = standard nucleotide base in which exocyclic amino and OH gps. are protected conventionally; R = H or if X = NH, an acid-labile protecting gp.; and R1 = protecting gp. labile towards acid but stable towards amine. Also new are the intermediates (IV). |
| priorityDate | 1995-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 86.