http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0761678-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a3e44e8a7bad23cd72efd76db5bde60b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-252 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-252 |
| filingDate | 1996-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6418137adbe8d0c1d697cc8756cef324 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2897a28ceb560cb2673d7a9c9ee52e5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a46bab678cf689957ff7b626277cec4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_240c515b3d3c11d3c0367f508104c952 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6733a271d7c7010bb2d81e21aa60b133 |
| publicationDate | 1997-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-0761678-A1 |
| titleOfInvention | Fluorine-containing anthracycline derivatives having hydroxyl group(s) mono- or di-o-aminoalkanoylated in the sugar moiety thereof |
| abstract | To provide novel fluorine-containing anthracycline derivatives having high antitumor activities and a solubility in water, there have now been synthesized a 7-O-(2,6-dideoxy-2-fluoro-3-O- or -4-O- or -3,4-di-O-aminoalkanoyl-α-L-talopyranosyl)daunomycinone or -adriamycinone of general formula (I) shown below, as well as a 7-O-(3-O- or -4-O-or -3,4-di-O-aminoalkanoyl-2,6-dideoxy-2,6,6,6-tetrafluoro-α-L-talopyranosyl- or -2,6-dideoxy-6,6,6-trifluoro-α-L-lyxo-hexopyranosyl)adriamycinone of general formula (II) shown below:-n n wherein either one or both of A 1 and A 2 is or are an α-amino acid residue or an ω-amino acid residue and T denotes a fluorine or hydrogen atom. The novel fluorine-containing anthracycline derivatives of general formulae (I) and (II) are highly active against tumors and soluble in water, and they are useful as antitumor agents administrable in the form of injectable solution. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1156056-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1156056-A4 |
| priorityDate | 1995-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 393.