| abstract |
An amide derivative represented by the following formula (1):n wherein R 1 represents a C 1-40 hydrocarbon; R 2 represents a C 1-6 alkylene; R 3 represents H, OH or alkoxyl; R 4 represents a C 1-39 hydrocarbon; R 5 representsn or -O-R 10 -R 11 , with the proviso that when R 5 representsn or -O-R 10 -R 11 , R 3 does not represent OH; and a composition of the amide derivative for topical application to human skin. The composition improves the barrier function of the stratum corneum, providing improvement and prevention of dermatitis, skin roughness, or similar disorders. |