| abstract |
A class of 3,4-diaryl substituted furan derivatives and analogs thereof, and pharmaceutical compositions containing them to treat skin-related disorders. Compounds of particular interest are defined by a formula selected fromn wherein X is hydrogen or hydroxy; wherein R 2 is aryl optionally substituted with a radical selected from halo, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, nitro, amino, sulfamyl and lower alkylsulfonylamino; and wherein R 3 is aryl optionally substituted with a radical selected from halo, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, nitro, amino, lower alkylamino, lower alkylsulfonylamino and sulfamyl; provided that at least one of R 2 and R 3 is substituted with methylsulfonyl or sulfamyl; or a pharmaceutically-acceptable salt thereof. |