| abstract |
An isolated and purified protein of the I-Domain from the human leukocyte β2-integrin Mac-1, expressed in recombinant Escherichia coli as a soluble fusion protein with glutathione S-transferase (GST). The protein, a functional derivative, fragment, analog or chemical derivative of such fragment is useful in the treatment of inflammation by interfering with the cell adhesion mechanism to block adhesion and migration of neutrophils. |