| abstract |
The present invention is to provide novel imidazole derivatives effectual as an antihyperlipemic agent and therapeutic and preventive drugs for arteriosclerosis, and to provide methods for manufacturing the said derivatives. n More particularly, the present invention is directed to the compounds represented by the following general formula [I];n wherein R 1 is hydrogen or lower alkyl, n is 0 or 1, X is N-r 1 wherein r 1 is hydrogen or lower alkyl, O, S, SO, SO 2 , CH 2 , CH(CH 3 ), CONH or C(r 2 )=NO wherein r 2 is hydrogen or lower alkyl, m is 0 or an integer of from 1 to 12, and A is methyl or a group represented by the following general formula;n wherein Y is N-r 3 wherein r 3 is hydrogen or lower alkyl, N(r 4 )SO 2 wherein r 4 is hydrogen or lower alkyl, O, S, SO, SO 2 , CH 2 , CH(CH 3 ), CONH or C(r 5 )=NO wherein r 5 is hydrogen or lower alkyl, R 2 is a halogen, a lower alkyl, a lower alkoxy, a cycloalkyl or COOr 6 wherein r 6 is hydrogen or a lower alkyl, and l is 0, 1, 2 or 3, however, m denotes an integer of from 6 to 9 when A is methyl, or m denotes 0 or an integer of from 1 to 6 when A is a group represented by the following general formula;n and X and Y are each independently CH 2 when m is 0, the pharmaceutically-acceptable salts thereof and methods for manufacturing the said compounds and the pharmaceutically-acceptable salts thereof. |