http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0751988-A4

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publicationDate 1997-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0751988-A4
titleOfInvention HIGH EFFICIENCY PRODUCTION AND INSULATION OF VIRAL PARTICLES
abstract This invention is directed to a continuous process for producing viral particles by providing in a perfused growth medium a population of viable virally infected non-lytic cells, and removing medium containing said cells at a rate to maintain the steady-state log-phase growth of cells remaining in the perfused growth medium. The invention is also directed to a process for purifying retroviral particles by passing a solution comprising the retroviral particles and contaminants through an anion exchange resin, and eluting the retroviral particles from the resin. The preferred exchange resin is a tentacle anion exchange resin.
priorityDate 1994-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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