| abstract |
Disclosed herein is a substituted piperidine derivative represented by the following general formula (1):n wherein R 1 means an aryl or heteroaryl group which may have at least one substituent, R 2 denotes an alkyl, alkenyl or aralkyl group, R 3 stands for a hydrogen atom or an alkyl group, and R 4 is a hydrogen atom, an alkyl group, or an aryl, heteroaryl, aralkyl, aralkenyl or heteroaralkyl group which may have at least one substituent, or a salt thereof. A medicine including this compound is also disclosed. The compound has excellent anticholinergic effect and calcium antagonism and inhibits reflex bladder contraction and is hence useful for prophylaxis of and treatment for a urinary disturbance such as pollakiuria. |