| abstract |
Cpds. of formula (I) are new, with the exception of sialyl Lewis-X and -A, and derivs. of these which contain a N3, NH2 or OH substit. in place of a N-acetyl gp., or contain glycerin in place of fucose: R<1>, R<2> = H, CH2X or CH2O(CH2)mX<1>; or R<1>+R<2> = a six-membered substd. carbo- or hetero-cycle; R<3> = O, S, H or CH2OX<2>; R<4>, R<5> = O- alpha -NANA (where NANA is N-acetylneuraminic acid), O- beta -NANA, OSO3H, or another monobasic acid; R<6> = H, OH or 1-25C alkyl; or R<6>+R<3> = a six-membered substd. carbo- or heterocycle; Y = O- alpha -NANA, O- beta -NANA, OSO3H, or another monobasic acid; Z = a pyranose, a furanose or an open-chain polyalcohol; m, n, p, q = 1-20; X, X<1>, X<2> = H, NH2, COOH, OH, CH2OH, CH2NH, aryl, 1-25C alkyl or CH2O(CH2)qX; X<3> = H, 1-25C alkyl or aryl; or X<3>+X<3> = O or S. |