| abstract |
Provided are pharmaceutical formulations, and methods of inhibiting fungal and parasitic activity using a compound of formula I <CHEM> wherein : R', R'', R"', R<x1>, R<x2>, R<y1>, R<y2>, R<y3>, R<y4> and R<0> are as defined hereinabove; and R<2> is <CHEM> R<3> is <CHEM> <CHEM> <CHEM> or <CHEM> R<3a>, R<3b>, R<3c> and R<3d> are independently hydrogen, C1-C12 alkyl, C2-C12 alkynyl, C1-C12 alkoxy, C1-C12 alkylthio, halo, or -O-(CH2)m-ÄO-(CH2)nÜp-O-(C1-C12 alkyl) or -O-(CH2)q-X-R<4>; m is 2, 3 or 4; n is 2, 3 or 4; p is 0 or 1; q is 2, 3 or 4; X is pyrrolidino, piperidino or piperazino; and R<4> is hydrogen, C1-C12 alkyl, C3-C12 cycloalkyl, benzyl or C3-C12 cycloalkylmethyl; or a pharmaceutically acceptable salt thereof.b |